RegenSeq Open Source Community

Transform Obsolete DNA Sequencers into Cutting-Edge Automation Platforms

RegenSeq is an NSF-funded open source ecosystem that repurposes decommissioned Illumina HiSeq 2500 DNA sequencers into flexible automation platforms for spatial biology research.

About RegenSeq

PySeq2500 is our Python-based control software that transforms obsolete scientific instruments into affordable, accessible tools for advanced single-cell assays and spatial transcriptomics/proteomics applications.

Features

Open Source Python Toolkit - Complete control software on GitHub
Custom Flow Cell Designs - Adapt for various spatial biology applications
Comprehensive Documentation - Step-by-step guides and API references
Active Community Support - Join researchers worldwide repurposing sequencers

Get Started

Visit our GitHub repository: https://github.com/nygctech/PySeq2500

Documentation: https://pyseq2500.readthedocs.io

Protocols: https://protocols.io/workspaces/regenseq

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